ABSTRACT
Objective: To observe the effect of modified Yinchen Wuling San in treating liver function and blood lipid of non-alcoholic fatty liver disease (NALFD) with moisture and heat implication and the mechanism on intestinal microflora. Method: One hundred and thirteen patients were randomly divided into control group (57 cases) and observation group (56 cases) by random number table according to SAS. Both groups'patients got non drug intervention. Patients in control group got polyene phosphatidylcholine capsules, 2 grains/time, 3 times/days, and live combined Bacillus subtilis and Enterococcus faecium Enteric-coated capsules, 2 grains/time, 3 times/days. In addition to therapy of control group, patients in observation was also given modified Yinchen Wuling San, 1 dose/day. The treatment in two groups continued for 12 weeks. Before and after treatment, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and intestinal microflora were detected. And CT and B-mode ultrasonography of abdomen were detected. And traditional Chinese medicine (TCM) syndromes were scored. Result: After treatment, levels of ALT and AST in observation group were lower than those in control group (Z=2.002, PPZ=1.955, PZ=2.002, PZ=1.961, PPPConclusion: Modified Yinchen Wuling San can protect liver function of NAFLD, regulate lipid metabolism, ameliorate intestinal microflora, and recover the ecological equilibrium of intestine, with a good clinical effect.